Explain Muscle Loss With Menopause
The study investigates mice whose ovaries were surgically removed as well as mice without the estrogen receptor in their muscle stem cells and evaluated muscles’ ability to regenerate.
It found that the loss of estrogen or genetic deletion of the estrogen receptor in muscle stem cells led to a 30 to 50 percent drop in muscle stem cell (also known as satellite cell) numbers across five different muscles. The surviving cells had severe difficulty reproducing themselves and generating new muscle after injury.
The study also included a collaboration with scientists in Finland who performed muscle biopsies in women shortly before and after the transition to menopause. This showed that in humans, the number of satellite cells correlated strongly with changing serum estrogen levels. “This is the first work to show that estrogen deficiency affects the number as well as the function of satellite cells,”
It has been known that estrogen replacement therapy for menopausal symptoms can help maintain muscle health. But such hormone replacement therapy which treats weakening muscles also raises the risk of cancer due to estrogen’s effects on tissues, such as those of the breast and endometrium.
The team showed that a new class of drug, known to interact with estrogen receptors in a way that doesn’t affect breast or endometrial tissue, was able to stimulate the estrogen signal in muscle stem cells and could potentially shield aging women from muscle stem cell decline due to menopause, without the risks associated with conventional hormone replacement therapy.
” It has long been known that male sex hormones promote muscle health, but we have been in the dark about what happens when females age,” “What estrogen does in women in terms of reproduction has been known for decades. Now we’re learning what estrogens do in women’s muscles.” Read more women’s clinic in Singapore
– Annual Gynecological review and Pap smear, Breast Cancer Screening, Mammogram Colposcopy for abnormal Pap smears (LEEP/LLETZ) (accredited by the Society for Colposcopy & Cervical Pathology of Singapore).
– Birth control advice and treatment.Treatment of Menopausal problems. Menopause management: Bone Mineral Density and Hormone Replacement Therapy (HRT) advice
– Gynecological surgery including laparoscopic surgery up to Level 3.
– Hysteroscopy – Diagnostic for Abnormal Uterine Bleeding and Heavy Menstrual Bleeding (Menorrhagia).
– Hysteroscopy – Operative for Removal of Endometrial polyps, Division of Uterine Septum, Division of Uterine.
– Adhesions, Endometrial Ablation or Resection of Endometrium (TCRE), Resection of Submucous Myomas (TCRM).
– Laparoscopy Diagnostic for Infertility Work-up, Pelvic Pain, Endometriosis, Ovarian Cysts, Ectopic Pregnancy.
– Laparoscopy Operative for Pelvic and Tubal Adhesions causing pain or infertility, Endometriosis, Ovarian Cysts, Fibroids,.
– Hysterectomy (total laparoscopic hysterectomy TLH, or laparoscopic-assisted vaginal hysterectomy LAVH),.
– Ectopic Pregnancy (salpingostomy – conserving tube, or salpingectomy removal of the tube).